The conundrum of hot mitochondria
نویسندگان
چکیده
The mitochondrion is often referred as the cellular powerhouse because organelle oxidizes organic acids and NADH derived from nutriments, converting around 40% of Gibbs free energy change these reactions into ATP, major currency cell metabolism. Mitochondria are thus microscopic furnaces that inevitably release heat a by-product reactions, this contributes to body warming, especially in endotherms like birds mammals. Over last decade, idea has emerged mitochondria could be warmer than cytosol, their intense It even been suggested our own operate under normal conditions at temperature close 50 °C, something difficult reconcile with laws thermal physics. Here, using combined expertise biology physics, we exhaustively review reports led concept hot mitochondrion, which essentially based on development use variety molecular thermosensors whose intrinsic fluorescence modified by temperature. Then, discuss physical concepts diffusion, including mechanisms phonons scattering, occur nanoscale range. Although most approaches studies present relatively sparse data lack absolute calibration, overall, they do support hypothesis mitochondria. However, there no convincing explanation would allow maintain higher its surroundings. We nevertheless proposed some research directions, mainly biological, might help throw light intriguing conundrum.
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Hot mitochondria?
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ژورنال
عنوان ژورنال: Biochimica Et Biophysica Acta - Bioenergetics
سال: 2021
ISSN: ['1879-2650', '0005-2728']
DOI: https://doi.org/10.1016/j.bbabio.2020.148348